31+ Otay Mesa Holiday Rentals & Private Villas

Find Family-Friendly Holiday Rentals in or near Otay Mesa

Discover more than 31 holiday rentals in Otay Mesa. Casai holiday homes have everything you need to find a place to stay near Otay Mesa, CA.

Whether you are looking for luxury villas in Otay Mesa, furnished homes, unique style condos, flats, cozy cottages for a romantic getaway, spacious apartments for family holidays, or stylish accommodations for a business trip, we can help you find the perfect place. Our holiday rentals include top amenities such as indoor/outdoor swimming pools, kitchen facilities, gyms, hot tubs, Internet connectivity, and more.

If you are planning to travel to Otay Mesa with a whole family or group, Casai holiday accommodations will make your trip memorable. We have plenty of places to stay in Otay Mesa for families, large parties, or private owner accommodations for long or short trips. Otay Mesa Pet-friendly holiday rentals are available. Book your favorite vacation rentals in Otay Mesa with Casai. Casai makes it easy to compare and book holiday rentals today.

Show more
Show less

Frequently Asked Questions About Otay Mesa Holiday Rentals

There are a lot of options in Otay Mesa. If you plan on staying in the Otay Mesa area, consider making a reservation for a few nights at one of these properties as these have been rated the top Holiday Home Rentals in Otay Mesa:

There are many holiday rentals available in Otay Mesa; however, here are a few of the most popular holiday homes listed in Otay Mesa on our website:
At Casai.co.za most of our places to stay are perfect for families. Check out the complete list of holiday homes in Otay Mesa to find one that works for you.
Yes, there are 31 self-catering family homes and holiday rentals in Otay Mesa.
There are more than 31 luxury holiday homes in or near Otay Mesa, according to 2025 data from Casai.co.za. Consider these homes for your next holiday:
Yes, there are 31 pet friendly rentals that are available in Otay Mesa.